STELARA® dosing and administration for adult patients with moderately to severely active UC

STELARA® OFFERS UNIQUELY DESIGNED DOSING IN UC1

Single IV induction dose followed by subQ maintenance treatments every 8 weeks
IV infusion icon

A Single IV Induction

Single IV induction dose administered over at least 1 hour

Body weight* of patient at the time of dosingDoseNumber of 130 mg/26 mL
(5 mg/mL) STELARA® vials
55 kg or less260 mg2
more than 55 kg to 85 kg390 mg3
more than 85 kg520 mg4
Injection icon

SubQ Maintenance†

90-mg dose every 8 weeks after induction dose

6 subQ maintenance doses during Year 1

For optimal outcome, STELARA® should be dosed and administered as described in the Prescribing Information

  • Please refer to the Dosage and Administration section of the full Prescribing Information for complete information on how to prepare and administer STELARA®
  • STELARA® is intended for use under the guidance and supervision of a physician with patients who will be closely monitored and have regular follow-up
  • Patients may self-inject with STELARA® after physician approval and proper training
  • Patients should be instructed to follow the direction provided in the Medication Guide

View dosing and administration of STELARA® in CD

CD=Crohn's disease; IV=intravenous; subQ=subcutaneous; UC=ulcerative colitis.

*Approximately 2.2 pounds per kilogram.

†Induction dose: A single IV infusion using a weight-based dosage regimen: STELARA® 260 mg (weight ≤55 kg), STELARA® 390 mg (weight >55 kg to 85 kg), STELARA® 520 mg (weight >85 kg). Maintenance dose: A subQ 90-mg dose administered every 8 weeks after the induction dose.

NUMBER OF DOSES AMONG SELECT UC+CD BIOLOGICS

Total doses in the first 52 weeks for adult patients

STELARA®1*

7

1 IV induction dose and 6 subQ injection maintenance doses for STELARA®1 IV induction dose and 6 subQ injection maintenance doses for STELARA®

Single IV weight-based induction dose administered over at least 1 hour; 6 subQ injection maintenance doses of 90 mg (1 every 8 weeks after induction dose).

Entyvio®(vedolizumab)2

8

3 IV infusion doses during induction and 5 IV infusion doses during maintenance period for Entyvio®

300-mg IV infusion, administered over a period of about 30 minutes, at 0, 2, and 6 weeks, and then every 8 weeks thereafter.

Humira® (adalimumab)3

27

3 starter injections in 2 doses during induction and 25 subQ injection maintenance doses for HUMIRA®

Three starter injections of 80 mg in 2 doses (on Day 1 and Day 15); 25 subQ injection maintenance doses of 40 mg (1 every other week thereafter).

KEY:

IV infusion icon

IV infusion

subQ injection pre-filled syringe icon

subQ injection
pre-filled syringes

subQ injection pen icon

subQ injection pen

This presentation is not intended to compare the relative safety or efficacy of these treatments. Please refer to each product’s full Prescribing Information.

Indicated trademarks are registered trademarks of their respective owners.

CD=Crohn's disease; IV=intravenous; subQ=subcutaneous; TNF=tumor necrosis factor; UC=ulcerative colitis.

*Induction dose: A single IV infusion using a weight-based dosage regimen: STELARA® 260 mg (weight ≤55 kg), STELARA® 390 mg (weight >55 kg to 85 kg), STELARA® 520 mg (weight >85 kg). Maintenance dose: A subQ 90-mg dose administered every 8 weeks after the induction dose.

†Based on 300 mg administered by IV.

‡The recommended dosing for Humira® is 160 mg initially on Day 1 (given in 1 day or split over 2 consecutive days), followed by 80 mg 2 weeks later (Day 15). Two weeks later (Day 29), begin a maintenance dose of 40 mg every other week.

WRITE 2 PRESCRIPTIONS FOR STELARA®1

One for the single IV induction dose* and 1 for subQ maintenance treatment
1 script for STELARA® IV induction dose and 1 script for STELARA® subQ maintenance dose

IV=intravenous; subQ=subcutaneous.

*The single IV infusion dose and number of vials are determined using a weight-based dosage regimen: STELARA® 260 mg (weight ≤55 kg), STELARA® 390 mg (weight >55 kg to 85 kg), or STELARA® 520 mg (weight >85 kg). Please refer to the full Prescribing Information for the complete dosing information.

IV=intravenous; subQ=subcutaneous.

References: 1. STELARA® [Prescribing Information]. Horsham, PA: Janssen Biotech, Inc. 2. Entyvio® [Prescribing Information]. Deerfield, IL: Takeda Pharmaceuticals America, Inc. 3. Humira® [Prescribing Information]. North Chicago, IL: AbbVie Inc.

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