STELARA® dosing and administration for adult patients with moderately to severely active UC
Single IV induction dose administered over at least 1 hour
Body weight* of patient at the time of dosing | Dose | Number of 130 mg/26 mL (5 mg/mL) STELARA® vials |
55 kg or less | 260 mg | 2 |
more than 55 kg to 85 kg | 390 mg | 3 |
more than 85 kg | 520 mg | 4 |
90-mg dose every 8 weeks after induction dose
6 subQ maintenance doses during Year 1
For optimal outcome, STELARA® should be dosed and administered as described in the Prescribing Information
CD=Crohn's disease; IV=intravenous; subQ=subcutaneous; UC=ulcerative colitis.
*Approximately 2.2 pounds per kilogram.
†Induction dose: A single IV infusion using a weight-based dosage regimen: STELARA® 260 mg (weight ≤55 kg), STELARA® 390 mg (weight >55 kg to 85 kg), STELARA® 520 mg (weight >85 kg). Maintenance dose: A subQ 90-mg dose administered every 8 weeks after the induction dose.
Single IV weight-based induction dose administered over at least 1 hour; 6 subQ injection maintenance doses of 90 mg (1 every 8 weeks after induction dose).
300-mg IV infusion, administered over a period of about 30 minutes, at 0, 2, and 6 weeks, and then every 8 weeks thereafter.
Three starter injections of 80 mg in 2 doses (on Day 1 and Day 15); 25 subQ injection maintenance doses of 40 mg (1 every other week thereafter).
KEY:
IV infusion
subQ injection
pre-filled syringes
subQ injection pen
This presentation is not intended to compare the relative safety or efficacy of these treatments. Please refer to each product’s full Prescribing Information.
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CD=Crohn's disease; IV=intravenous; subQ=subcutaneous; TNF=tumor necrosis factor; UC=ulcerative colitis.
*Induction dose: A single IV infusion using a weight-based dosage regimen: STELARA® 260 mg (weight ≤55 kg), STELARA® 390 mg (weight >55 kg to 85 kg), STELARA® 520 mg (weight >85 kg). Maintenance dose: A subQ 90-mg dose administered every 8 weeks after the induction dose.
†Based on 300 mg administered by IV.
‡The recommended dosing for Humira® is 160 mg initially on Day 1 (given in 1 day or split over 2 consecutive days), followed by 80 mg 2 weeks later (Day 15). Two weeks later (Day 29), begin a maintenance dose of 40 mg every other week.
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IV=intravenous; subQ=subcutaneous.
*The single IV infusion dose and number of vials are determined using a weight-based dosage regimen: STELARA® 260 mg (weight ≤55 kg), STELARA® 390 mg (weight >55 kg to 85 kg), or STELARA® 520 mg (weight >85 kg). Please refer to the full Prescribing Information for the complete dosing information.
IV=intravenous; subQ=subcutaneous.
References: 1. STELARA® [Prescribing Information]. Horsham, PA: Janssen Biotech, Inc. 2. Entyvio® [Prescribing Information]. Deerfield, IL: Takeda Pharmaceuticals America, Inc. 3. Humira® [Prescribing Information]. North Chicago, IL: AbbVie Inc.